Cheng Zhang

  • Associate professor

  • Peking University

  • zhangcheng369@pku.edu.cn

Basic Information

张成，1980年出生，北京大学计算机学院，副研究员，博士生导师。 围绕生物和信息交叉技术领域（BT&IT）前沿探索，围绕前瞻分子信 息处理技术全链条“DNA存储-电路计算-数据操控-信息读取”开展创新 研究。申请人作为第一或通讯作者，以国内机构为第一完成单位，发表 论文40余篇，包括：Nature (2024), Nature Communications (20 23), Science Advances (2022), Angew. Chem. Int. Ed. (2023) , J. Am. Chem. Soc. (2019), ACS nano (2024, 2025), Small (202 3, 2024), Nucleic Acids Research (2020, 2019, 2018), IEEE TNB ( 2025), Biosensors & Bioelectronics (2021),中国科学 （2015）, 科学通报 （2014）等学术期刊（图1）。申请人承担国家及省部级科研项目多 项：国家重点研发计划重点专项项目（2024，主持)和课题（2021，主持）、 中央军委装备预研基础研究专项（2023，主持）、重点研发计划“政府间科技合 作”项目（2019，主持）、国家自然科学基金面上等项目（2013、2017、2019 、2023，主持）、教育部装备联合基金项目（2018，主持）、北京市联合研发专 项项目（2021，主持）、北京市自然基金（2018，主持）等科研项目。获得201 2年教育部自然科学一等奖：《DNA计算机相关理论与应用研究》（排名5）；20 23年教育部自然科学二等奖：《基于DNA的分子信息处理研究》（排名3）。2020年 ，入选中国科学院创新交叉团队。2022年，入选中国智能计算科技创新人物（生物计算领域）。

Publications

  • Cheng Zhang, Ranfeng Wu, Fajia Sun, Yisheng Lin, Yuan Liang, Jiongjiong Teng, Na Liu, Qi Ouyang, Long Qian, Hao Yan. Parallel molecular data storage by printing epigenetic bits on DNA. Nature, 634, 824-832, 2024.
  • Liang Yuan, Qie Yunkai, Jing Yang, Wu Ranfeng, Cui Shuang, Zhao Yuliang, Greg J. Anderson, Guangjun Nie, Suping Li, Zhang Cheng. Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction. Nature Communications, 14, 4898, 2023.
  • Jing Yang, Yuan Liang, Xiang Li, Yongpeng Zhang, Long Qian, Yonggang Ke, Zhang Cheng. Spatially Programmable Enzymatic Nanorobot Arm to Modulate Anisotropic Gold Nanoparticle Assembly. Angewandte Chemie International Edition, 62, e202308797, 2023.
  • Zhang Cheng, Xueying Ma, Xuedong Zheng, Yonggang Ke, Kuiting Chen, Dongsheng Liu, Zuhong Lu, Jing Yang, Hao Yan. Programmable Allosteric DNA Regulations for Molecular Networks and Nanomachines. Science advances, 8, eabl4589, 2022.
  • Zhang Yongpeng, Chen Yiming, Liu Xuan, Ling Qian, Wu Ranfeng, Yang Jing, Zhang Cheng. Programmable Primer Switching for Regulating Enzymatic DNA Circuits. ACS nano, 18, 5089−5100, 2024.
  • Ranfeng Wu, Yiming Chen, Yongpeng Zhang, Rongming Liu, Qiang Zhang, Zhang Cheng. Catalytic Gold Nanoparticle Assembly Programmed by DNAzyme Circuits. Small, 2307107, 2024.
  • Jing Yang, Juan Wang, Xuan Liu, Yiming Chen, Yuan Liang, Qi Wang, Shuoxing Jiang, Zhang Cheng. Translocation of Proteins through Solid-State Nanopores Using DNA Polyhedral Carriers. Small, 2303715, 2023.
  • Taoli Ding, Jing Yang, Victor Pan, Zuhong Lu, Yonggang Ke, Zhang Cheng. Shaped DNA Origami Carrier Nanopore Translocation Influenced by Aptamer based Surface Modification. Biosensors & Bioelectronics, 195, 113658, 2021.
  • Taoli Ding, Jing Yang, Victor Pan, Nan Zhao, Zuhong Lu, Yonggang Ke, Zhang Cheng. DNA nanotechnology assisted nanopore-based analysis. Nucleic Acids Research, 48, 2791-2806, 2020.
  • Zhang Cheng, Zhiyu Wang, Yan Liu, Jing Yang, Xinxin Zhang, Linqiang Pan, Yonggang Ke, Hao Yan. Nicking Assisted Reactant Recycle to Implement Entropy-Driven DNA Circuit. J. Am. Chem. Soc., 141, 17189-17197, 2019.
  • Xuedong Zheng, Jing Yang, Changjun Zhou, Cheng Zhang, Qiang Zhang, Xiaopeng Wei. Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis. Nucleic Acids Research, 47, 1097-1109, 2019.
  • Linqiang Pan, Yingxin Hu, Taoli Ding, Zhiyu Wang, Chun Xie, Zhekun Chen, Jing Yang, Zhang Cheng. Aptamer-based regulation of transcription circuits. Chemical Communications, 55, 7378-7318, 2019.
  • Jing Yang, Ranfeng Wu, Zhiyu Wang, Linqiang Pan, Qiang Zhang, Zuhong Lu, Zhang Cheng. Entropy-Driven DNA Logic Circuits Regulated by DNAzyme. Nucleic Acids Research, 46, 8532-8541, 2018.
  • Linqiang Pan, Zhiyu Wang, Fanyi Li, Jing Yang, Qiang Zhang, Zhang Cheng. Nicking enzyme-controlled toehold regulation for DNA logic circuits. Nanoscale, 9, 18223-18228, 2017.
  • Zhang Cheng, Ranfeng Wu, Yifan Li, Qiang Zhang, Jing Yang. Programmable Regulation of DNA Conjugation to Gold Nanoparticles via Strand Displacement. Langmuir, 33, 12285-12290, 2017.
  • Zhang Cheng, Jing Yang, Shuoxing Jiang, Yan Liu and Hao Yan. DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly. Nano Letters, 16, 736-741, 2016.
  • Jing Yang, Shuoxing Jiang, Xiangrong Liu, Linqiang Pan, Zhang Cheng. Aptamer-Binding Directed DNA Origami Pattern for Logic Gates. ACS Appl. Mater. Interfaces, 8, 34054-34060, 2016.
  • Jing Yang, Zhichao Song, Shi Liu, Qiang Zhang, Zhang Cheng. Dynamically arranging gold nanoparticles on DNA origami for molecular logic gates. ACS Appl. Mater. Interfaces, 81, 22451-22456, 2016.
  • Yongpeng Zhang, Xuan Liu, Siqi Hou, Ranfeng Wu, Jing Yang, Zhang Cheng. Enzyme-Programmed Self-Assembly of Nanoparticles. Chembiochem, 25, e202400384, 2024.
  • Jing Yang, Nan Zhao, Yuan Liang, Zuhong Lu, Cheng Zhang. Structure-flexible DNA origami translocation through a solid-state nanopore. RSC Advances, 11, 23471-23476, 2021.
  • Yongpeng Zhang, Yuhua Feng, Yuan Liang, Jing Yang, Zhang Cheng. Development of Synthetic DNA Circuit and Networks for Molecular Information Processing. Nanomaterials, 4, 2955-2970, 2021.
  • Yafei Dong, Chen dong, Fei Wan, Jing Yang, Cheng Zhang. Development of DNA computing and information processing based on DNA-strand displacement, Science China (Chemistry), 1515-1523, 2015.
  • Jing Yang, Jingjing Ma, Shi Liu, Zhang Cheng. A molecular cryptography model based on structures of DNA self-assembly, Chinese Science Bulletin, 59, 1192-1198, 2014.

AWARDS & HONORS:

  • 2012年教育部自然科学一等奖：“DNA计算机相关理论与应用研究”
  • 2023年教育部自然科学二等奖：“基于 DNA 的分子信息处理研究”
  • 2020年，入选中国科学院创新交叉团队
  • 2023年，入选中国智能计算科技创新人物

Research project

  • (1) National Key R&D Program of the Ministry of Science and Technology (China)
    Research on Novel DNA Information Security Technology Based on Non-Traditional Molecular Bit Molecular Storage, 2025.
  • (2) Preliminary Research Project (China)
    Nanopore Access DNA Storage Technology with Molecular Tags, 2023.
  • (3) National Natural Science Foundation (China)
    Research on DNA Circuits Based on Adaptive Regulation Mechanisms, 2023.
  • (4) National Key R&D Program of the Ministry of Science and Technology (China)
    Development of Multi-Media Transferable DNA Storage Data Processing System, 2021.
  • (5) Zhejiang Lab Open Project (China)
    Research on DNA Storage Technology Based on Biomimetic Molecular Circuits, 2022.
  • (6) National Key R&D Program of China, Key Project of Intergovernmental International Cooperation (China)
    Detection of Biomacromolecules Based on DNA Self-Assembled Composite Nanopore Technology, 2019.
  • (7) Beijing Collaborative Joint R&D and Large Science Program (China)
    Research on Composite Nanopore Devices Based on DNA Self-Assembly, 2021.
  • (8) National Natural Science Foundation (China)
    Fluorescence Sensor-Based DNA Computing System, 2019.
  • (9) Ministry of Education Joint Fund (China)
    Research on Molecular Self-Assembled Nano 3D Printing Technology, 2018.
  • (10) Beijing Natural Science Foundation (China)
    Variable Structure Solid-State Nanopores Combined with DNA Self-Assembly, 2018.
  • (11) National Natural Science Foundation (China)
    Research on Self-Assembled DNA Nanoparticle Computing Models, 2013.
  • (12) National Natural Science Foundation (China)
    Research on Computational Model of Self-Assembled DNA Nanoparticles.